2-(4-Chlorophenoxy)-5-nitropyridine → 6-(4-Chlorophenoxy)pyridin-3-amine

HRID 1156210ノート

反応式

HRID 1156210 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]=2)=[CH:4][CH:3]=1.[H][H]>O1CCCC1.C(OCC)(=O)C.[Pt](=O)=O>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][N:8]=2)=[CH:4][CH:3]=1

参加物

6

反応物 2

HCID 2771852-(4-Chlorophenoxy)-5-nitropyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 4206446-(4-Chlorophenoxy)pyridin-3-amine収率 94.2%

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

4-Chlorophenoxy-5-nitropyridine (19.9 g) and platinum dioxide (0.1 g) were suspended in a mixture of tetrahydrofuran (100 ml) and ethyl acetate (50 ml), and catalytic reduction was carried out until 5.0 liters of hydrogen were absorbed. After removal of the catalyst by filtration, the solvent was distilled out under reduced pressure. The precipitated crystals were washed with a small amount of ether to give 16.5 g of 4-chlorophenoxy-5-aminopyridine as white crystals. M.P., 87°-88° C.

後処理

  1. customwere absorbed
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. distillationthe solvent was distilled out under reduced pressure
  5. washThe precipitated crystals were washed with a small amount of ether

出典と根拠

ORDレコード
ord-17fe63a8741e42b2941a15393552ca86
出典データセット
uspto-grants-1982_06
特許番号
US04334912

反応ノート

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