Thionyl Chloride → N-(2-chloroethyl)-4-fluoro-2-nitrobenzamide

HRID 1156330ノート

反応式

HRID 1156330 の反応式
[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][CH2:9][CH2:10]O)=[O:7])=[C:4]([N+:14]([O-:16])=[O:15])[CH:3]=1.S(Cl)([Cl:19])=O>ClC(Cl)Cl>[Cl:19][CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]1[CH:12]=[CH:13][C:2]([F:1])=[CH:3][C:4]=1[N+:14]([O-:16])=[O:15]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 202789664-fluoro-N-(2-hydroxyethyl)-2-nitrobenzamide

生成物 1

HCID 20278955N-(2-chloroethyl)-4-fluoro-2-nitrobenzamide収率 83%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 28 parts of 4-fluoro-N-(2-hydroxyethyl)-2-nitrobenzamide, 40 parts of thionyl chloride and 150 parts of trichloromethane is stirred and refluxed for 2 hours. After cooling, the precipitated product is filtered off and dried, yielding 24.5 parts (83%) of N-(2-chloroethyl)-4-fluoro-2-nitrobenzamide.

後処理

  1. temperaturerefluxed for 2 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitated product is filtered off
  4. customdried

出典と根拠

ORDレコード
ord-c69bea10de1049e4bde92ac30d02d961
出典データセット
uspto-grants-1982_06
特許番号
US04335127

反応ノート

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