Ethylmorpholine → HCID 54377318、化合物

HRID 1156476ノート

反応式

HRID 1156476 の反応式
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1)=O.[C:12](#[N:15])[CH:13]=C.C(N1CCOCC1)C>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1(OC)C=CC=CC=1>[CH:7]([C:6]1[CH:10]=[CH:11][C:3]([CH:1]=[CH:13][C:12]#[N:15])=[CH:4][CH:5]=1)=[O:8]

参加物

6

反応物 3

HCID 7525EthylmorpholineHCID 7855AcrylonitrileHCID 124246204-Formylbenzoyl chloride

生成物 1

HCID 54377318HCID 54377318、化合物収率 52%

試薬・触媒・溶媒 2

HCID 167845palladium(II) acetate触媒HCID 7519Anisole溶媒

反応条件

温度
120 °C

実験手順

0.0018 g (0.008 millimol) of palladium acetate, 6.74 g (40 millimols) of 4-formylbenzoyl chloride, 3.29 g (50 millimols) of acrylonitrile and 5.12 ml (40 millimols) of N-ethylmorpholine are added to 80 ml of anisole. The mixture is stirred for 12 hours at 120° C., under argon. The crude product is distilled in vacuo and is then recrystallised from isopropanol. 3.2 g (52% of theory) of 4-formylcinnamonitrile are obtained in the form of white crystals.

後処理

  1. distillationThe crude product is distilled in vacuo
  2. customis then recrystallised from isopropanol

出典と根拠

ORDレコード
ord-50fd0df2de054cd5a9f01846ffd56c0f
出典データセット
uspto-grants-1982_06
特許番号
US04335054

反応ノート

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