Water → 2-Chloro-4-phenylthiazole-5-carboxylic acid

HRID 1156604ノート

反応式

HRID 1156604 の反応式
[Cl:1][C:2]1[S:3][C:4]([C:13]([O:15]CC)=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[OH-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[S:3][C:4]([C:13]([OH:15])=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13041816Ethyl 2-chloro-4-phenyl-1,3-thiazole-5-carboxylate

生成物 1

HCID 130418282-Chloro-4-phenylthiazole-5-carboxylic acid収率 90.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 53.4 g (0.2 mole) of ethyl 2-chloro-4-phenyl-5-thiazolecarboxylate, 8.0 g (0.2 mole) of NaOH, 200 ml. of water and 400 ml. of tetrahydrofuran was stirred for 16 hours and extracted with ether. The organic layer was discarded. The aqueous layer was made acidic and the precipitate was collected and air-dried to give 43.2 g (90%) of the desired product, m.p. 170°-171° C.

後処理

  1. extractionextracted with ether
  2. customthe precipitate was collected
  3. customair-dried

出典と根拠

ORDレコード
ord-037f94191c814069bad2c02e159ffa2a
出典データセット
uspto-grants-1982_06
特許番号
US04336389

反応ノート

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