Sodium Iodide → 2-[2-(3-chloro-4-fluorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]-N-isopropylacetamide

To a suspension of 2-[2-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide (120 mg, 0.26 mmol) in acetonitrile (1 mL) was added K2CO3 (178 mg, 1.29 mmol), piperidine (0.76 mL, 0.77 mmol) and sodium iodide (20 mg, 0.13 mmol). The resultant mixture was heated to 80° C. in a tightly capped vial with stirring for 20 h. The mixture was then cooled to room temperature and poured into ice water (8 mL). The resultant white solid was collected by filtration and the filter cake was washed with cold diethyl ether (3×10 mL). The crude product was purified by chromatography on silica gel with methanol:dichloromethane (1:9, v/v) as eluent to afford 2-[2-(3-chloro-4-fluorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]-N-isopropylacetamide (120 mg, 0.23 mmol, 91%). The HCl salt was prepared by treating the freebase with 5% HCl in ethanol (xs.) followed by removal of the ethanolic HCl in vacuo. The resultant HCl salt was redissolved in ethanol and the ethanol removed in vacuo (3×) to help remove residual HCl. The HCl salt thus obtained was then triturated with diethyl ether and collected by filtration affording 2-[2-(3-chloro-4-fluorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]-N-isopropylacetamide hydrochloride (EXAMPLE 2a) as a white crystalline solid.

1. filtrationThe resultant white solid was collected by filtration
2. washthe filter cake was washed with cold diethyl ether (3×10 mL)
3. customThe crude product was purified by chromatography on silica gel with methanol:dichloromethane (1:9, v/v) as eluent

ORDレコード

ord-edbf97c0ed6d4455a5e7987402f595f9

出典データセット

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07807686B2