Morpholine → 4-(5-Bromopyrazin-2-yl)morpholine

HRID 1157809ノート

反応式

HRID 1157809 の反応式
[H-].[Na+].[NH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[Br:9][C:10]1[C:15](Br)=[N:14][CH:13]=[CH:12][N:11]=1>C1COCC1>[Br:9][C:10]1[N:11]=[CH:12][C:13]([N:3]2[CH2:8][CH2:7][O:6][CH2:5][CH2:4]2)=[N:14][CH:15]=1

参加物

5

反応物 3

HCID 8083MorpholineHCID 24758Sodium hydrideHCID 138675722,3-Dibromopyrazine

生成物 1

HCID 457874804-(5-Bromopyrazin-2-yl)morpholine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To sodium hydride (0.20 g) taken in THF (15 ml), morpholine (0.735 ml) was added under nitrogen, at 0° C. The reaction mixture stirred for about 15 minutes, then 2,3-dibromopyrazine (2 g) dissolved in dry THF (15 ml) was added. The reaction mixture was allowed to stir at reflux conditions for overnight. The reaction mixture was quenched with water (5 ml), and volatiles were removed under vacuum. The resulting crude mass was purified by column chromatography to afford pure 4-(5-bromopyrazin-2-yl)morpholine.

後処理

  1. additionwas added
  2. stirringto stir
  3. temperatureat reflux conditions for overnight
  4. customThe reaction mixture was quenched with water (5 ml), and volatiles
  5. customwere removed under vacuum
  6. customThe resulting crude mass was purified by column chromatography

出典と根拠

ORDレコード
ord-e745a98e4fa24b41968cda4677f6a632
出典データセット
uspto-grants-2010_10
特許番号
US07807676B2

反応ノート

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