Methyl iodide → Ethyl 2-(pyridin-4-yl)propanoate

HRID 1158061ノート

反応式

HRID 1158061 の反応式
[Li]N([Si](C)(C)C)[Si](C)(C)C.[N:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:13][CH:12]=1.[CH3:23]I>C1COCC1>[N:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 736321Ethyl pyridine-4-acetateHCID 178418261HCID 178418261、化合物

生成物 1

HCID 11651240Ethyl 2-(pyridin-4-yl)propanoate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of LiN(TMS)2 (Aldrich, 1.0 M solution in THF, 30 mL, 30 mmol) in THF (30 mL) was added ethyl 4-pyridylacetate (Aldrich, 4.7 mL, 30 mmol)) at 0° C. Methyl iodide (Aldrich, 2.4 mL, 38 mmol) was added 30 min later. After 1 h, the reaction mixture was concentrated in vacuo. The crude product was purified by silica gel chromatography. Mass Spec. m/z+ion 180 (M+1).

後処理

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customThe crude product was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-7b348aade2a44a4897ead385b0bf66b6
出典データセット
uspto-grants-2010_10
特許番号
US07807700B2

反応ノート

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