Hydrochloric Acid → 7-Tert-butyl-chroman-4-ol

HRID 1158784

反応式

HRID 1158784 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][CH2:10][CH:11]1[O:16]CCCO1)([CH3:4])([CH3:3])[CH3:2].Cl>O1CCCC1.C(OCC)C>[C:1]([C:5]1[CH:6]=[C:7]2[C:17]([CH:11]([OH:16])[CH2:10][CH2:9][O:8]2)=[CH:18][CH:19]=1)([CH3:2])([CH3:3])[CH3:4]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 595485522-[2-(3-Tert-butyl-phenoxy)-ethyl]-[1,3]dioxane

生成物 1

HCID 595485267-Tert-butyl-chroman-4-ol

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The intermediate from step A was dissolved in 20 ml tetrahydrofuran. Concentrated hydrochloric acid (20 mL) was added, and the reaction mixture was stirred at ambient temperature for 4 hours, diluted with diethyl ether and washed with water. The isolated organic layer was dried with magnesium sulfate, filtered and the solvent removed under reduced pressure to give 2.87 g of crude 7-tert-butyl-chroman-4-ol which was used without further purification.

後処理

  1. washwashed with water
  2. dry with materialThe isolated organic layer was dried with magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-d25c8a5b32e84a68a77b3e7aee1f0cba
出典データセット
uspto-grants-2010_10
特許番号
US07812019B2

関連ノート

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