{4H,5H,6H-pyrrolo[1,2-b]pyrazol-2-yl}methanol → 4H,5H,6H-pyrrolo(1,2-b)pyrazole-2-carbaldehyde

HRID 1158858ノート

反応式

HRID 1158858 の反応式
[N:1]1[N:2]2[CH2:10][CH2:9][CH2:8][C:3]2=[CH:4][C:5]=1[CH2:6][OH:7]>O=[Mn]=O.C(Cl)(Cl)Cl>[N:1]1[N:2]2[CH2:10][CH2:9][CH2:8][C:3]2=[CH:4][C:5]=1[CH:6]=[O:7]

参加物

4

反応物 1

HCID 21941359{4H,5H,6H-pyrrolo[1,2-b]pyrazol-2-yl}methanol

生成物 1

HCID 112864914H,5H,6H-pyrrolo(1,2-b)pyrazole-2-carbaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6212Chloroform溶媒

実験手順

MnO2 (activated) (24.4 g) was added to the CHCl3 (350 mL) solution of (5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)methanol (4.87 g) and refluxed for 1 h under a nitrogen atmosphere. The reaction mixture was filtered through a pad of Celite. The filtrate was reduced under reduced pressure. The residue was applied to silica gel column chromatography, then the column was eluted with n-hexane-AcOEt (1/1-1/2). The title compound was obtained as yellow oil (4.35 g, 91%).

後処理

  1. temperaturerefluxed for 1 h under a nitrogen atmosphere
  2. filtrationThe reaction mixture was filtered through a pad of Celite
  3. washthe column was eluted with n-hexane-AcOEt (1/1-1/2)

出典と根拠

ORDレコード
ord-174db0ed55454fdab55623d8c8603c9c
出典データセット
uspto-grants-2010_10
特許番号
US07812014B2

反応ノート

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