Triethylamine → HCID 68644788、化合物

HRID 1159002

反応式

HRID 1159002 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([OH:12])=O)=[CH:4][CH:3]=1.ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.C(N(CC)CC)C.[NH2:42][C:43]1[CH:44]=[C:45]2[C:49](=[CH:50][CH:51]=1)[N:48]([CH2:52][C:53]([C:61]1[CH:66]=[CH:65][C:64]([F:67])=[CH:63][C:62]=1[F:68])([OH:60])[CH2:54][N:55]1[CH:59]=[N:58][CH:57]=[N:56]1)[N:47]=[CH:46]2>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5](/[CH:8]=[CH:9]/[C:10]([NH:42][C:43]2[CH:44]=[C:45]3[C:49](=[CH:50][CH:51]=2)[N:48]([CH2:52][C:53]([C:61]2[CH:66]=[CH:65][C:64]([F:67])=[CH:63][C:62]=2[F:68])([OH:60])[CH2:54][N:55]2[CH:59]=[N:58][CH:57]=[N:56]2)[N:47]=[CH:46]3)=[O:12])=[CH:6][CH:7]=1

参加物

7

反応物 5

HCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 737158(2E)-3-(4-bromophenyl)prop-2-enoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 68644438(5-Amino-1H-indazol-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

生成物 1

HCID 68644788HCID 68644788、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution, of (E)-3-(4-bromophenyl)acrylic acid (0.034 g, 0.15 mmol) in tetrahydrofuran (1 ml) were added 1-hydroxybenzotriazole (0.023 g, 0.17 mmol) and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.032 g, 0.17 mmol). Then triethylamine (0.045 ml, 0.32 mmol) was slowly added at 0° C., followed by stirring the reaction mixture for 30 min. After the addition of (5-Amino-1H-indazol-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (0.057 g, 0.15 mmol) and 4-N,N-dimethylaminopyridine (0.004 g, 0.03 mmol), stirring at room temperature for 2 hours and concentrated by evaporation in a vacuum condition. The crude product was purified by chromatography on silica gel to give the title compound.

後処理

  1. stirringstirring at room temperature for 2 hours
  2. concentrationconcentrated by evaporation in a vacuum condition
  3. customThe crude product was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-c4c96a3e664e4c379dc799aefdcf6148
出典データセット
uspto-grants-2010_10
特許番号
US07812045B2

関連ノート

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