Acetonitrile → 1-Benzyl-1H-indole-3-carboxylic acid pyrimidin-4-ylamide

HRID 1159134

反応式

HRID 1159134 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]([OH:19])=O)=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[N:22][CH:21]=1.CC#N>O=S(Cl)Cl.CN1C(=O)CCC1>[N:20]1[CH:25]=[CH:24][C:23]([NH:26][C:17]([C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:9]=2)=[O:19])=[N:22][CH:21]=1

参加物

6

反応物 3

HCID 6342AcetonitrileHCID 336711-benzyl-1H-indole-3-carboxylic acidHCID 689584-Aminopyrimidine

生成物 1

HCID 595139721-Benzyl-1H-indole-3-carboxylic acid pyrimidin-4-ylamide

試薬・触媒・溶媒 2

HCID 13387N-methyl-2-pyrrolidone溶媒HCID 24386Thionyl Chloride溶媒

実験手順

1-Benzylindole-3-carboxylic acid (25.9 mg, 96 mmol) was dissolved in SOCl2 (1 mL) and the mixture was stirred for 30 min before the volatiles were removed in vacuo. The residue was dissolved in MeCN (200 μL) and added to a solution of pyrimidin-4-yl-amine (10 mg, 105 mmol) in NMP (200 μL). The reaction mixture was stirred 16 hours at room temperature before the MeCN was removed in vacuo. The residue was purified using HPLC method D to give title compound.

後処理

  1. customwere removed in vacuo
  2. dissolutionThe residue was dissolved in MeCN (200 μL)
  3. customwas removed in vacuo
  4. customThe residue was purified

出典と根拠

ORDレコード
ord-481fb1c78bb44715b4b824227f0f607e
出典データセット
uspto-grants-2010_10
特許番号
US07812043B2

関連ノート

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