Phosphorus pentachloride → 4-(Methylsulfonyl)benzenemethanesulfonyl chloride

HRID 1159468ノート

反応式

HRID 1159468 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][S:12]([OH:15])(=O)=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[Na].P(Cl)(Cl)(Cl)(Cl)[Cl:18]>C(Cl)(Cl)Cl>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][S:12]([Cl:18])(=[O:15])=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

参加物

5

反応物 3

HCID 24819Phosphorus pentachlorideHCID 5360545SodiumHCID 17973788(4-Methanesulfonyl-phenyl)-methanesulfonic acid

生成物 1

HCID 219624184-(Methylsulfonyl)benzenemethanesulfonyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To the title A compound, (4-methanesulfonyl-phenyl)-methanesulfonic acid, sodium salt is added PCl5 (10 g) in 200 mL of chloroform and the mixture is stirred for 48 h. The solids are filtered off, the chloroform is removed by evaporation, and the residue is triturated with hexanes, and the solids are collected by filtration to afford (4-methanesulfonyl-phenyl)-methanesulfonyl chloride.

後処理

  1. filtrationThe solids are filtered off
  2. customthe chloroform is removed by evaporation
  3. customthe residue is triturated with hexanes
  4. filtrationthe solids are collected by filtration

出典と根拠

ORDレコード
ord-825b500b5e5f4abaaab796bd4af3530e
出典データセット
uspto-grants-2010_10
特許番号
US07812167B2

反応ノート

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