Methyl [4-methyl-2-(4-nitrobenzyl)-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate → Methyl[2-(4-aminobenzyl)-4-methyl-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate

HRID 1159676

反応式

[CH3:1][C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[N:5]=[C:4]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=2)[N:3]=1>C1COCC1.[Pd]>[NH2:25][C:22]1[CH:21]=[CH:20][C:19]([CH2:18][C:4]2[N:3]=[C:2]([CH3:1])[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6]([N:13]3[CH2:14][CH2:15][CH2:16][CH2:17]3)[N:5]=2)=[CH:24][CH:23]=1

参加物

実験手順

To a solution of methyl [4-methyl-2-(4-nitrobenzyl)-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate (0.074 g, 0.20 mmol) in anhydrous THF (2 mL) was added Pd/C (10% Pd, 0.050 g) and the resulting black suspension was stirred under an atmosphere of hydrogen. After 1 hour; the reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to give methyl [2-(4-aminobenzyl)-4-methyl-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate.

後処理

filtrationthe reaction mixture was filtered through Celite
concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード: ord-d993a29578204d6cad6ac097abef3441
出典データセット: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07812160B2

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

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