[CH3:1][S:2](Cl)(=[O:4])=[O:3].CN(C)C=O.O1CCCC1.[NH2:16][C:17]1[CH:37]=[CH:36][C:20]([O:21][CH2:22][CH2:23][O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH:31]([CH3:35])[C:32]([OH:34])=[O:33])=[CH:19][CH:18]=1>N1C=CC=CC=1>[CH3:1][S:2]([NH:16][C:17]1[CH:18]=[CH:19][C:20]([O:21][CH2:22][CH2:23][O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH:31]([CH3:35])[C:32]([OH:34])=[O:33])=[CH:36][CH:37]=1)(=[O:4])=[O:3]38 mg (0.332 mM) of methanesulfonyl chloride are added to a mixture of 0.25 ml of dimethylformamide and 1.5 ml of tetrahydrofuran in a 15 ml reactor. 100 mg (0.332 mM) of 2-{2-(4-aminophenoxy)ethoxy}phenylpropanoic acid are then added, followed by addition of 0.060 ml (0.74 mM) of pyridine. The reaction medium is then stirred for 48 hours at room temperature. After extraction with ethyl acetate, 20 mg of 2-{2-[4-(methylsulfonylamino)phenoxy]ethoxy}phenyl-propanoic acid are obtained (yield: 16%).
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