Ethanol → N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine

HRID 1162001ノート

反応式

HRID 1162001 の反応式
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[O:17][CH:16]=[CH:15][C:14]=3[CH:13]=[C:12]([N+:19]([O-])=O)[CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O)C.O.NN>C1COCC1.[Ni]>[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[O:17][CH:16]=[CH:15][C:14]=3[CH:13]=[C:12]([NH2:19])[CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

6

反応物 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 66893941HCID 66893941、化合物2 回

生成物 1

HCID 86058078N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

(2-Morpholin-4-ylethyl)(5-nitro-1-benzofuran-7-yl)amine (450 mg, 1.545 mmol; Intermediate 27) was dissolved in THF (5 mL). After addition of ethanol (100 mL), Raney-nickel (cat.) and hydrazine hydrate (2 mL), the mixture was left stirring at room temperature for 2 h. The product was used directly in the subsequent reaction after filtration through Celite and evaporation of solvent.

後処理

  1. waitthe mixture was left
  2. customThe product was used directly in the subsequent reaction
  3. filtrationafter filtration
  4. customthrough Celite and evaporation of solvent

出典と根拠

ORDレコード
ord-0f165c00b7cd496896c1e4dd1ff174f4
出典データセット
uspto-grants-2010_10
特許番号
US07820675B2

反応ノート

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