Oxalyl chloride → 4-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride

HRID 1162602ノート

反応式

HRID 1162602 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([OH:17])=O)[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:21])=O>C(Cl)(Cl)Cl>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([Cl:21])=[O:17])[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 207501802-Thiazolecarboxylic acid, 4-[4-(1-methylethyl)phenyl]-

生成物 1

HCID 860798104-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

4-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride was prepared by refluxing a mixture of 4-(4-Isopropyl-phenyl)-thiazole-2-carboxylic acid (50 mg) and oxalyl chloride (300 μl) in chloroform (5 mL). After 3 h, the volatiles were evaporated and the residue was dried under high vacuum to provide the acid chloride (50 mg).

後処理

  1. temperatureby refluxing
  2. customthe volatiles were evaporated
  3. customthe residue was dried under high vacuum

出典と根拠

ORDレコード
ord-52b0ee15dd494030b44d3c5b9a598395
出典データセット
uspto-grants-2010_10
特許番号
US07820704B2

反応ノート

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