N-bromobutanimide → 2-Methoxyphenyl 2-methoxy-3-bromomethylphenyl ether

反応式

[Br:1]N1C(=O)CCC1=O.[CH3:9][O:10][C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH3:26]>C1C=CC=CC=1.N(C(C)(C)C#N)=NC(C)(C)C#N>[CH3:9][O:10][C:11]1[C:16]([CH2:17][Br:1])=[CH:15][CH:14]=[CH:13][C:12]=1[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH3:26]

参加物

実験手順

N-Bromosuccinimide (6.56 g) and 2,2'-azobisisobutyronitrile (100 mg) were added to a solution of 2-methoxyphenyl 2-methoxy-3-methylphenyl ether (9.0 g) in benzene (100 ml), and the mixture was refluxed under heating for 2 hrs. The reaction mixture was evaporated, and water was added to the residue. The mixture was extracted with diethyl ether, and the extract was washed with water, dried over magnesium sulfate and then evaporated to give oily residue of 2-methoxyphenyl 2-methoxy-3-bromomethylphenyl ether (12.10 g).