Thionyl Chloride → 2-Chlorophenyl 2-methoxy-3-chloromethylphenyl thioether

HRID 1164080ノート

反応式

HRID 1164080 の反応式
[CH3:1][O:2][C:3]1[C:10]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.S(Cl)([Cl:21])=O>N1C=CC=CC=1.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]([CH2:5][Cl:21])=[CH:7][CH:8]=[CH:9][C:10]=1[S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18]

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 53999561HCID 53999561、化合物

生成物 1

HCID 205134642-Chlorophenyl 2-methoxy-3-chloromethylphenyl thioether

試薬・触媒・溶媒 2

HCID 1049Pyridine触媒HCID 241Benzene溶媒

実験手順

A mixture of 2-methoxy-3-(2-chlorophenylthio)benzyl alcohol (9 g), thionyl chloride (4.6 ml) and pyridine (3 drops) in dried benzene (60 ml) was refluxed under heating for 30 minutes. The reaction mixture was cooled to the ambient temperature and evaporated under reduced pressure. The residue was dissolved in diethyl ether, and the solution was washed with water, saturated aqueous sodium bicarbonate and water in turn, dried over magnesium sulfate and then evaporated under reduced pressure to give oily 2-chlorophenyl 2-methoxy-3-chloromethylphenyl thioether (9.2 g).

後処理

  1. temperaturewas refluxed
  2. temperatureunder heating for 30 minutes
  3. customevaporated under reduced pressure
  4. dissolutionThe residue was dissolved in diethyl ether
  5. washthe solution was washed with water, saturated aqueous sodium bicarbonate and water in turn
  6. dry with materialdried over magnesium sulfate
  7. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-ee3ee6d3e94e4c04bc8dd8a29e34a833
出典データセット
uspto-grants-1983_01
特許番号
US04367238

反応ノート

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