Thionyl Chloride → o-Tolyl 2-methoxy-3-chloromethylphenyl thioether

HRID 1164109ノート

反応式

HRID 1164109 の反応式
[CH3:1][O:2][C:3]1[C:10]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.S(Cl)([Cl:21])=O>N1C=CC=CC=1.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]([CH2:5][Cl:21])=[CH:7][CH:8]=[CH:9][C:10]=1[S:11][C:12]1[C:13]([CH3:18])=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 545312442-Methoxy-3-(o-tolylthio)benzyl alcohol

生成物 1

HCID 20513475o-Tolyl 2-methoxy-3-chloromethylphenyl thioether

試薬・触媒・溶媒 2

HCID 1049Pyridine触媒HCID 241Benzene溶媒

実験手順

A mixture of 2-methoxy-3-(o-tolylthio)benzyl alcohol (8.5 g), thionyl chloride (4.8 ml) and pyridine (3 drops) in benzene (80 ml) was stirred at room temperature and then at 80° C. for 10 minutes. The reaction mixture was treated in a similar manner to that of Example 21-(6) to give oily o-tolyl 2-methoxy-3-chloromethylphenyl thioether (8.3 g).

後処理

  1. additionThe reaction mixture was treated in a similar manner to that of Example 21-(6)

出典と根拠

ORDレコード
ord-64b00faca09a4b24b115632615958d21
出典データセット
uspto-grants-1983_01
特許番号
US04367238

反応ノート

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