Potassium Carbonate → HCID 178502891、化合物

HRID 1164130

反応式

HRID 1164130 の反応式
[Cl:1][C:2]1[C:3]([C:12]([OH:14])=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.S(Cl)(Cl)=O.ClC1C(C(Cl)=O)=NC=C(C(F)(F)F)C=1.Cl.[CH3:34][O:35][NH2:36].C(=O)([O-])[O-].[K+].[K+]>>[CH3:34][O:35][N:36]=[C:12]([C:3]1[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:5][N:4]=1)[OH:14]

参加物

6

反応物 5

HCID 11430Potassium CarbonateHCID 24386Thionyl ChlorideHCID 521874O-Methylhydroxylamine hydrochlorideHCID 28219083-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acidHCID 220135553-Chloro-5-trifluoromethyl-pyridine-2-carbonyl chloride

生成物 1

HCID 178502891HCID 178502891、化合物

実験手順

For example, 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid is reacted with thionyl chloride whereby 3-chloro-5-trifluoromethylpicolinoyl chloride can be obtained. This compound is reacted with O-methylhydroxyamine hydrochloride at room temperature for 4 hours in the presence of potassium carbonate to obtain N-methoxy-3-chloro-5-trifluoromethylpyridine-2-carboximidic acid which is then reacted with O,O-diethylthionophospholic acid diester chloride at 50° C. for 24 hours in the presence of potassium carbonate to thereby obtain O,O-diethyl-O-(N-methoxy-3-chloro-5-trifluoromethylpyridine-2-carboximidoyl)thionophosphate (nD16.0 = 1.5054).

後処理

  1. customcan be obtained

出典と根拠

ORDレコード
ord-4bb67fd5170049c6971c9cc801db676f
出典データセット
uspto-grants-1983_01
特許番号
US04367336

関連ノート

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