(+-)-4-Hydroxymandelic acid → Sodium 4-hydroxyphenylglycolate

HRID 1164267

反応式

HRID 1164267 の反応式
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1.[OH-].[Na+:14]>C(C(C)=O)C(C)C>[OH:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([O-:9])=[O:8])=[CH:4][CH:3]=1.[Na+:14]

参加物

4

反応物 2

HCID 328(+-)-4-Hydroxymandelic acidHCID 14798Sodium Hydroxide

生成物 1

HCID 23663713Sodium 4-hydroxyphenylglycolate

試薬・触媒・溶媒 1

HCID 7909Methyl Isobutyl Ketone溶媒

反応条件

温度
20 °C

実験手順

The procedure of Example 1 was repeated except that the organic phase containing p-hydroxymandelic acid was treated with a molar equivalent of sodium hydroxide as a 50% w/w aqueous solution. The caustic solution was added over one hour during which time the methyl isobutyl ketone solution was maintained at about 20° C. with cooling. The precipitate of sodium p-hydroxymandelate monohydrate was filtered off and suctioned as dry as possible before drying under vacuum at 40° C.

後処理

  1. temperaturewith cooling
  2. filtrationThe precipitate of sodium p-hydroxymandelate monohydrate was filtered off
  3. customas dry as possible
  4. custombefore drying under vacuum at 40° C.

出典と根拠

ORDレコード
ord-efc510c327f446478b2c1dfe275dffcd
出典データセット
uspto-grants-1983_01
特許番号
US04368334

関連ノート

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