Methyl iodide → 1-Chloro-4-methoxy-2-methyl-5-nitrobenzene

HRID 1166231

反応式

HRID 1166231 の反応式
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.CI.[C:15](=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([O:9][CH3:15])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1

参加物

4

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 235324-Chloro-5-methyl-2-nitrophenol

生成物 1

HCID 158645661-Chloro-4-methoxy-2-methyl-5-nitrobenzene収率 97.3%

実験手順

4-Chloro-5-methyl-2-nitroanisole was prepared by the same procedure as described for Step 2 of Preparation 2a except using 4-chloro-5-methyl-2-nitrophenol (50 g), methyl iodide (75.8 g), and potassium carbonate (44 g). Workup gave crude 4-chloro-5-methyl-2-nitroanisole (52.3 g, 97%) which was used in the next step without purification. 1H NMR (300 MHz, CDCl3) δ7.85 (s, 1 H), 6.95 (s, 1 H), 3.94 (s, 3 H), 2.45 (s, 3 H).

後処理

  1. custom4-Chloro-5-methyl-2-nitroanisole was prepared by the same procedure

出典と根拠

ORDレコード
ord-6cdaa4c65f6b40d1b63eb5d209868180
出典データセット
uspto-grants-2003_09
特許番号
US06613786B2

関連ノート

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