Hydrogen Bromide → 1-Bromo-3-[(4-chlorophenoxy)phenyl]-2-propanone

HRID 1166325ノート

反応式

HRID 1166325 の反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8](Cl)=[CH2:9])=[CH:4][CH:3]=1.BrN1[C:18](=O)[CH2:17][CH2:16][C:15]1=O.[BrH:21].[C:22](#N)[CH3:23].[OH2:25]>CCOCC>[Br:21][CH2:22][C:23](=[O:25])[CH2:9][C:8]1[CH:15]=[CH:16][CH:17]=[CH:18][C:7]=1[O:6][C:5]1[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=1

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 67184N-bromobutanimideHCID 122548641-(4-Chlorophenoxy)-2-chloro-2-propeneHCID 18373917Acetonitrile--water (1/1)

生成物 1

HCID 229980221-Bromo-3-[(4-chlorophenoxy)phenyl]-2-propanone収率 54%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a turbid solution of 1-(4-chlorophenoxy)-2-chloro-2-propene from Step 1 (3 g, 15.7 mmol) in acetonitrile/water (4/1, 100 mL), N-bromosuccinimide (4.84 g, 31.4 mmol) was added in one lot. A catalytic amount of 48% HBr (40 μl) was added to the reaction and the yellowish orange mixture was stirred at room temperature. After 24 hours, the reaction mixture was diluted with ether and washed with 5% w/v of sodium thiosulfate. The organic layer was separated and washed with saturated sodium bicarbonate and brine. After drying (MgSO4), filtration and concentration in vacuo, the crude liquid (4.8 g) was purified by chromatography (silica gel, hexane/ethyl acetate, 80/20) to give crude 1-bromo-3-[(4-chlorophenoxy)phenyl]-2-propanone (2.3 g, 54%) which was used in the next step without further purification.

後処理

  1. washwashed with 5% w/v of sodium thiosulfate
  2. customThe organic layer was separated
  3. washwashed with saturated sodium bicarbonate and brine
  4. customAfter drying
  5. filtration(MgSO4), filtration and concentration in vacuo
  6. customthe crude liquid (4.8 g) was purified by chromatography (silica gel, hexane/ethyl acetate, 80/20)

出典と根拠

ORDレコード
ord-9006e5bdd1a5497ca8e591aa2237dcd7
出典データセット
uspto-grants-2003_09
特許番号
US06613789B2

反応ノート

読み込み中…