Dimethylformamide → (S)-3-Cyclohexylbutyroyl Chloride
反応式
[C:1]1([C@@H:7]([CH3:12])[CH2:8][C:9](O)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>CO.C1(C)C=CC=CC=1.[Rh]>[CH:1]1([C@@H:7]([CH3:12])[CH2:8][C:9]([Cl:16])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
7
実験手順
(S)-3-phenylbutyric acid was hydrogenated using Rh/C in MeOH at 60 psi and 60° C. for 3.2 hours. The reduced product was then converted to the title acid chloride by treating with 1 eq of oxalyl chloride, and a catalytic amount of DMF, in toluene for 90 minutes, followed by evaporation of the volatile materials.
後処理
- customat 60 psi and 60° C.
- customfor 3.2 hours
- customfollowed by evaporation of the volatile materials
出典と根拠
- ORDレコード
- ord-e425d4f156254adc9d08a4f60024b1b6
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06613880B2
反応ノート
読み込み中…