Sodium Iodide → Methyl 5-amino-6-chloro-2-phenylimidazo[1,2-a]pyridine-8-carboxylate

反応式

[NH2:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]([Cl:12])=[C:4]([NH2:13])[N:3]=1.Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=O.[I-].[Na+]>>[NH2:13][C:4]1[N:3]2[CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:1]=[C:2]2[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[Cl:12]

参加物

反応物 3

HCID 5238Sodium Iodide

HCID 6259Phenacyl bromide

HCID 12088100Methyl 2,6-Diamino-5-chloronicotinate

生成物 1

HCID 22992224Methyl 5-amino-6-chloro-2-phenylimidazo[1,2-a]pyridine-8-carboxylate

実験手順

The title compounds were prepared according to the procedure described in the step 2 in EXAMPLE 1 (METHOD B) using methyl 2,6-diamino-5-chloro-3-pyridinecarboxylate (EXAMPLE 1, METHOD B, Step 1), 2-bromoacetophenone and sodium iodide.

出典と根拠

ORDレコード: ord-f0774e76eff3468db6465d77bf9f8e14
出典データセット: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06624162B2

反応ノート

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