Ethyl Bromide → 3-Ethyl-quinolino[5,6-d]imidazolinone

反応式

[NH:1]1[C:5]2[C:6]3[CH:7]=[CH:8][CH:9]=[N:10][C:11]=3[CH:12]=[CH:13][C:4]=2[NH:3][C:2]1=[O:14].[H-].[Na+].Br[CH2:18][CH3:19]>>[CH2:18]([N:3]1[C:4]2[CH:13]=[CH:12][C:11]3[N:10]=[CH:9][CH:8]=[CH:7][C:6]=3[C:5]=2[NH:1][C:2]1=[O:14])[CH3:19]

参加物

反応物 3

HCID 6332Ethyl Bromide

HCID 24758Sodium hydride

HCID 140867271H-Imidazo[4,5-f]quinolin-2(3H)-one

生成物 1

HCID 698658863-Ethyl-quinolino[5,6-d]imidazolinone

実験手順

3-Ethyl-quinolino[5,6-d]imidazolinone (1f) was prepared analogously by treatment of quinolino[5,6-d]imidazolinone with sodium hydride (1.1 eq.) and bromoethane (1.1 eq.), successively. Yield after column-chromatographic workup: 12%. Mp. 258-259° C.