Water → 1-Bromo-2-(propoxymethyl)benzene

HRID 1169474ノート

反応式

HRID 1169474 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[H-].[Na+].Br[CH2:13][CH2:14][CH3:15].O>C1COCC1>[CH2:13]([O:5][CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[Br:1])[CH2:14][CH3:15]

参加物

6

反応物 4

HCID 962WaterHCID 78401-BromopropaneHCID 24758Sodium hydrideHCID 728502-Bromobenzyl alcohol

生成物 1

HCID 229900231-Bromo-2-(propoxymethyl)benzene

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Into a solution of 2-bromobenzyl alcohol (10.0 g) in THF (100 ml) was added at 0° C. sodium hydride (60%, 2.35 g), and the resulting mixture was stirred at room temperature for 2 hours. 1-Bromopropane (5.8 ml) was added to the reaction mixture, which was stirred at 60° C. for 20 hours. The reaction mixture was mixed with water and was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated solution of sodium chloride and was dried with magnesium sulfate. After concentration under reduced pressure, the residue was subjected to separation and purification using column chromatography (ethyl acetate:hexane 1:9) to obtain 2-bromobenzyl propyl ether (7.88 g) as a colorless oily substance.

後処理

  1. stirringwas stirred at 60° C. for 20 hours
  2. extractionwas extracted with ethyl acetate
  3. washThe organic layer was washed with an aqueous saturated solution of sodium chloride
  4. dry with materialwas dried with magnesium sulfate
  5. concentrationAfter concentration under reduced pressure
  6. customthe residue was subjected to separation and purification

出典と根拠

ORDレコード
ord-9c017f2c0c924d51b06146f08378ef2e
出典データセット
uspto-grants-2003_09
特許番号
US06627651B1

反応ノート

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