Thionyl Chloride → 4-Chloromethyl-1,2-diethoxy-benzene

HRID 1169504ノート

反応式

HRID 1169504 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH2:7]O)[CH3:2].S(Cl)([Cl:17])=O>C1(C)C=CC=CC=1.N1C=CC=CC=1.C(OCC)(=O)C>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH2:7][Cl:17])[CH3:2]

参加物

6

反応物 2

HCID 24386Thionyl ChlorideHCID 8540533,4-Diethoxybenzyl alcohol

生成物 1

HCID 24348314-Chloromethyl-1,2-diethoxy-benzene

試薬・触媒・溶媒 3

HCID 1049Pyridine触媒HCID 1140Toluene溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 3,4-diethoxybenzyl alcohol (736 mg) dissolved in toluene (10 ml) were added pyridine (one drop) and thionyl chloride (0.41 ml), and the resulting mixture was stirred at room temperature for 20 minutes. The reaction mixture was diluted with ethyl acetate and the resulting mixture was washed with water, an aqueous saturated solution of sodium hydrogen carbonate and an aqueous saturated solution of sodium chloride, and was dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain 3,4-diethoxybenzyl chloride (802 mg) as an oil.

後処理

  1. washthe resulting mixture was washed with water
  2. dry with materialan aqueous saturated solution of sodium hydrogen carbonate and an aqueous saturated solution of sodium chloride, and was dried with anhydrous magnesium sulfate
  3. customThe resulting organic layer was evaporated under reduced pressure
  4. customto remove the solvent

出典と根拠

ORDレコード
ord-77130ba029794686932449271b456b3a
出典データセット
uspto-grants-2003_09
特許番号
US06627651B1

反応ノート

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