Acrylonitrile → 4-Cyano-2-diaminomethylene-butyric acid ethyl ester

HRID 1171184ノート

反応式

HRID 1171184 の反応式
Cl.[CH2:2]([O:4][C:5](=[O:10])[CH:6]=[C:7]([NH2:9])[NH2:8])[CH3:3].C(N(CC)CC)C.[C:18](#[N:21])[CH:19]=[CH2:20]>O1CCCC1>[CH2:2]([O:4][C:5](=[O:10])[C:6]([CH2:20][CH2:19][C:18]#[N:21])=[C:7]([NH2:9])[NH2:8])[CH3:3]

参加物

5

反応物 3

HCID 7855AcrylonitrileHCID 8471TriethylamineHCID 124946853,3-Diamino-acrylic acid ethyl ester hydrochloride

生成物 1

HCID 124949064-Cyano-2-diaminomethylene-butyric acid ethyl ester収率 25%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The resulting 3,3-diamino-acrylic acid ethyl ester hydrochloride (2.2 g, 13.2 mmol) was suspended in tetrahydrofuran (40 mL) followed by the addition of triethylamine (2 mL, 14.3 mmol) and acrylonitrile (1.2 mL, 19.3 mmol) and refluxing while heating for 6 hours. Following completion of the reaction, the resulting triethylamine hydrochloride was filtered out and the filtrate was concentrated to obtain the title compound (0.6 g, 3.3 mmol, 25%).

後処理

  1. temperaturerefluxing
  2. temperaturewhile heating for 6 hours
  3. customcompletion of the reaction
  4. filtrationthe resulting triethylamine hydrochloride was filtered out
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-2ca895c509b94913a9a403f59a44bd3b
出典データセット
uspto-grants-2010_11
特許番号
US07829585B2

反応ノート

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