6-(methanesulfonyloxymethyl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)pyridin-2-amine → Diisopropylethylamine

HRID 1172415ノート

反応式

HRID 1172415 の反応式
CS(O[CH2:6][C:7]1[N:12]=[C:11](NC2C=CN(COCC[Si](C)(C)C)N=2)[CH:10]=C[CH:8]=1)(=O)=O.Cl.Cl[C:29]1[C:30](F)=C(C=C[CH:42]=1)C(N1CCNCC1)=O>C(Cl)(Cl)Cl>[CH:29]([N:12]([CH2:11][CH3:10])[CH:7]([CH3:6])[CH3:8])([CH3:30])[CH3:42]

参加物

4

反応物 2

HCID 575626516-(methanesulfonyloxymethyl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)pyridin-2-amineHCID 686779601-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

生成物 1

HCID 81531Diisopropylethylamine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 10 mg of 6-(methanesulfonyloxymethyl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)pyridin-2-amine, 40 mg of 1-(3-chloro-2-fluorobenzoyl)piperazine hydrochloride obtained in Reference Example 1, 27 μl of N,N-diisopropylethylamine and 1 ml of chloroform was stirred at 60° C. for 5 hours. The reaction solution was diluted with chloroform, and then washed with water and brine. The resulting organic layer was dried over magnesium sulfate and filtered, and the filtrate was concentrated. The resulting residue was purified by a silica gel column chromatography(eluent: chloroform to chloroform/methanol=20/1) to give the title compound.

出典と根拠

ORDレコード
ord-2cec57032c634c608d5df6a315a2e8f6
出典データセット
uspto-grants-2010_11
特許番号
US07834018B2

反応ノート

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