4-Bromobenzoic acid → 4-Bromo-3-(chlorosulfonyl)benzoic acid
反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Br:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1>>[Br:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[S:2]([Cl:1])(=[O:5])=[O:3]参加物
3
反応条件
- 温度
- 110 °C
実験手順
Chlorosulfonic acid (70 mL, 1.05 mol) cooled to 0° C. was added dropwise with stirring to 4-bromo-benzoic acid (50 g, 0.29 mol). The reaction mixture was heated at 110° C. for 10 h, cooled to room temperature and poured onto crushed ice slowly with stirring. The title compound obtained was filtered, washed with water and dried. Yield: 51 g, (84%); mp: 198-199° C.; MS: m/e (EI+) 299 (M+).
後処理
- additionwas added dropwise
- temperaturecooled to room temperature
- additionpoured
- customonto crushed ice slowly
出典と根拠
- ORDレコード
- ord-c21e3b7638a140fda12598cc8ceb3bd3
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834001B2
反応ノート
読み込み中…