O-Phenylenediamine → Methyl 2-{[(2-aminophenyl)amino]carbonyl}-1-benzothiophene-6-carboxylate

HRID 1172849ノート

反応式

HRID 1172849 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[CH:12]=[C:11]([C:13]([OH:15])=O)[S:10][C:9]=2[CH:16]=1)=[O:4].CCN=C=NCCCN(C)C.[CH:28]1[CH:29]=[CH:30][C:31]2[N:36](O)N=[N:34][C:32]=2[CH:33]=1.C1(N)C=CC=CC=1N>CN(C=O)C>[NH2:34][C:32]1[CH:33]=[CH:28][CH:29]=[CH:30][C:31]=1[NH:36][C:13]([C:11]1[S:10][C:9]2[CH:16]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[CH:6]=[CH:7][C:8]=2[CH:12]=1)=[O:15]

参加物

6

反応物 4

HCID 7243O-PhenylenediamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 595564196-(Methoxycarbonyl)benzo[b]thiophene-2-carboxylic acid

生成物 1

HCID 57624546Methyl 2-{[(2-aminophenyl)amino]carbonyl}-1-benzothiophene-6-carboxylate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of benzo[b]thiophene-2,6-dicarboxylic acid 6-methyl ester (129 mg, 0.543 mmol) in DMF (4 mL) was added EDCI (125 mg, 0.652 mmol), HOBt (88 mg, 0.652 mmol). The reaction mixture was stirred for 20 min and phenylene diamine (147 mg, 1.36 mmol) was added. After 18 h, the solvent was removed and EtOAc and H2O were added. The resultant solid was filtered yielding the desired product. 1H NMR (CDCl3, 600 MHz) δ 8.53 (s, 1H), 8.01 (s, 1H), 7.99 (d, J=7.9 Hz, 1H), 7.86 (d, J=7.9 Hz, 1H), 7.23 (d, J=6.8 Hz, 1H), 7.05 (t, J=6.8 Hz, 1H), 6.81 (d, J=6.8 Hz, 1H), 6.80 (t, J=6.8 Hz, 1H), 3.90 (s, 3H). MS: cal'd 327 (MH+), exp 327 (MH+).

後処理

  1. waitAfter 18 h
  2. customthe solvent was removed
  3. additionEtOAc and H2O were added
  4. filtrationThe resultant solid was filtered

出典と根拠

ORDレコード
ord-f7a81dc934d0475ba431e2e6d94f78de
出典データセット
uspto-grants-2010_11
特許番号
US07834034B2

反応ノート

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