Sodium hydride → 1-Propyl-1H-imidazole-2-carbaldehyde
反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=[O:7].I[CH2:9][CH2:10][CH3:11].[H-].[Na+]>CN(C=O)C>[CH2:9]([N:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=[O:7])[CH2:10][CH3:11]参加物
5
実験手順
In DMF 15 ml, 2-imidazole carboxaldehyde (500 mg) was dissolved. Then, the solution was added with 1-iodopropane (1.52 ml) and sodium hydride (208 mg), followed by stirring at room temperature for 5 days. After completion of the reaction, the solvent was distilled off and the residue was then added with chloroform, followed by washing with water and saturated saline solution. The resultant was dried with anhydrous sodium sulfate, and the solvent was distilled off. Then, the residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (600 mg) as a yellow oily substance.
後処理
- customAfter completion of the reaction
- distillationthe solvent was distilled off
- additionthe residue was then added with chloroform
- washby washing with water and saturated saline solution
- dry with materialThe resultant was dried with anhydrous sodium sulfate
- distillationthe solvent was distilled off
- customThen, the residue was purified through silica gel column chromatography (chloroform/methanol)
出典と根拠
- ORDレコード
- ord-56a6287295714ef2ad08f967e3ddf6f3
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07833991B2
反応ノート
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