Ammonium formate → 2-Methyloctahydropyrrolo(3,4-c)pyrrole

HRID 1174699ノート

反応式

HRID 1174699 の反応式
[CH2:1]([N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][N:12](C)[CH2:13]2)[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:1][N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][NH:12][CH2:13]2)[CH2:9]1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 129585342-Benzyl-5-methyloctahydropyrrolo[3,4-c]pyrrole

生成物 1

HCID 129585332-Methyloctahydropyrrolo(3,4-c)pyrrole

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 2-benzyl-5-methyloctahydropyrrolo[3,4-c]pyrrole (2.4 g) in methanol (60 ml) was mixed with ammonium formate (2.1 g) and palladium on carbon (5%, 0.12 g), and the mixture was refluxed for 8 hours. After cooling, the reaction solution was filtered and concentrated. The crude product could be directly reacted further. The product with the molecular weight of 126.20 (C7H14N2); MS (ESI): 127 (M+H+) was obtained in this way.

後処理

  1. temperaturethe mixture was refluxed for 8 hours
  2. temperatureAfter cooling
  3. filtrationthe reaction solution was filtered
  4. concentrationconcentrated
  5. customThe crude product could be directly reacted further
  6. customMS (ESI): 127 (M+H+) was obtained in this way

出典と根拠

ORDレコード
ord-acd9209c378d4023ba6e4dd1e5c6a91f
出典データセット
uspto-grants-2010_11
特許番号
US07838547B2

反応ノート

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