Sodium Hydroxide → HCID 67111612、化合物

HRID 1177401ノート

反応式

HRID 1177401 の反応式
[C:1]1([C:7]([C:9]2[N:14]=[C:13]3[S:15][C:16]([C:18]([O:20]CC)=[O:19])=[N:17][C:12]3=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:24]>C1COCC1>[C:1]1([C:7]([C:9]2[N:14]=[C:13]3[S:15][C:16]([C:18]([O-:20])=[O:19])=[N:17][C:12]3=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+:24]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67111591Ethyl 5-(1-phenylvinyl)thiazolo[5,4-b]pyridine-2-carboxylate

生成物 1

HCID 67111612HCID 67111612、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

To a solution of ethyl 5-(1-phenylvinyl)thiazolo[5,4-b]pyridine-2-carboxylate (1.04 g, 3.35 mmol) in THF (12.9 mL) was added sodium hydroxide (1.0N, aq.) (3.35 mL, 3.35 mmol), and the resulting suspension was stirred at 25° C. for 5 min. The reaction solution was subsequently concentrated in vacuo at 25° C. to provide sodium 5-(1-phenylvinyl)thiazolo[5,4-b]pyridine-2-carboxylate as a light-orange solid.

後処理

  1. concentrationThe reaction solution was subsequently concentrated in vacuo at 25° C.

出典と根拠

ORDレコード
ord-1396d8daf2324c1fa14bd866947fa770
出典データセット
uspto-grants-2010_11
特許番号
US07842685B2

反応ノート

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