Tetrahydrofuran → 2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(4-phenylocta-1,7-dien-4-yl)thiazolo[5,4-b]pyridine

HRID 1177431ノート

反応式

HRID 1177431 の反応式
[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[S:14][C:15]3[C:20]([N:21]=2)=[CH:19][CH:18]=[C:17]([CH:22]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:23][CH2:24][CH:25]=[CH2:26])[N:16]=3)=[C:9]([F:33])[CH:8]=1.C[Si]([N-][Si](C)(C)C)(C)C.[Na+].O1C[CH2:47][CH2:46][CH2:45]1.C(I)C=C>CN(C=O)C>[O:3]1[CH2:4][CH2:5][CH2:6][O:1][CH:2]1[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[S:14][C:15]3[C:20]([N:21]=2)=[CH:19][CH:18]=[C:17]([C:22]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)([CH2:23][CH2:24][CH:25]=[CH2:26])[CH2:47][CH:46]=[CH2:45])[N:16]=3)=[C:9]([F:33])[CH:8]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 11166Allyl iodideHCID 2724254Sodium bis(trimethylsilyl)amideHCID 686359872-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(1-phenylpent-4-enyl)thiazolo[5,4-b]pyridine

生成物 1

HCID 671119362-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(4-phenylocta-1,7-dien-4-yl)thiazolo[5,4-b]pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Argon was bubbled through a slurry of 2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)-5-(1-phenylpent-4-enyl)thiazolo[5,4-b]pyridine (1.02 g, 2.21 mmol) in 20 mL DMF for 5 min. The slurry was treated with sodium bis(trimethylsilyl)amide, 1.0M solution in tetrahydrofuran (2.66 mL, 2.66 mmol) rapidly via syringe, to give a dark blue solution. After 2 min, allyl iodide (0.306 mL, 3.32 mmol) was added via syringe, and the color gradually faded from blue to light brown. After 1 h, the reaction mixture was quenched with sat'd aq. NH4Cl and MTBE. The organic layer was washed with water, brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The resulting oil was dissolved in DCM, adsorbed onto 7 g silica gel, dried, and purified by silica gel chromatography ISCO, 40 g, gradient, 0-50% EA/hexanes, to give 2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)-5-(4-phenylocta-1,7-dien-4-yl)thiazolo[5,4-b]pyridine as a light yellow foam MS (ESI) m/z: Calculated: 500.2; Observed: 501.1 (M++1).

後処理

  1. customto give a dark blue solution
  2. waitAfter 1 h
  3. customthe reaction mixture was quenched with sat'd aq. NH4Cl and MTBE
  4. washThe organic layer was washed with water, brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. dissolutionThe resulting oil was dissolved in DCM
  9. customdried
  10. custompurified by silica gel chromatography ISCO, 40 g, gradient, 0-50% EA/hexanes

出典と根拠

ORDレコード
ord-bd589779f203493d88979e23dce3aafd
出典データセット
uspto-grants-2010_11
特許番号
US07842685B2

反応ノート

読み込み中…