反応式
CCN([CH:7]([CH3:9])C)C(C)C.[S:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[C:15]([OH:17])=O.C1C=CC2N([OH:27])N=NC=2C=1.CCN=C=NCCC[N:36]([CH3:38])C.Cl.CN([CH:43]=[O:44])C>O>[CH2:7]([O:27][C:43](=[O:44])[CH2:38][NH:36][C:15]([C:11]1[S:10][CH:14]=[CH:13][CH:12]=1)=[O:17])[CH3:9]参加物
7
反応物 5
生成物 1
試薬・触媒・溶媒 1
実験手順
DIPEA (0.472 mL, 2.73 mmol) was added to a stirred solution of thiophene-2-carboxylic acid (100 mg, 0.78 mmol) in DMF (1 mL). HOBT (126 mg, 0.94 mmol) and EDCI.HCl (179 mg, 0.94 mmol) were added, followed by the addition of ethyl glycine ester hydrochloride (119 mg, 0.86 mmol) at room temperature. The reaction mixture was stirred at room temperature overnight. The mixture was then diluted with water and the product extracted with EtOAc. The organic layer was washed with brine solution, dried over Na2SO4 and concentrated under reduced pressure to afford [(thiophene-2-carbonyl)-amino]-acetic acid ethyl ester in 84% yield, LC-MS purity: 97%
後処理
- extractionthe product extracted with EtOAc
- washThe organic layer was washed with brine solution
- dry with materialdried over Na2SO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-0ad602b5b6da40e4b3275d6dce37e755
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07842696B2
関連ノート
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