N-bromobutanimide → HCID 22053533、化合物

HRID 1180506ノート

反応式

HRID 1180506 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1.[Br:22]N1C(=O)CCC1=O>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)[CH:5]=[N:6][C:7]=1[Br:22]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 11717372HCID 11717372、化合物

生成物 1

HCID 22053533HCID 22053533、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 1-(5-bromo-3-pyridyl)-4-tert-butoxycarbonylhomopiperazine (2.68 g, 7.5 mmol), N-bromosuccinimide (1.34 g, 7.5 mmol) and acetonitrile (75 ml) was stirred for 30 minutes. The crude mixture was evaporated and purified by chromatography on silica gel using ethyl acetate: petroleum (2:1) as solvent. Yield 3.0 g, 92%.

後処理

  1. customThe crude mixture was evaporated
  2. custompurified by chromatography on silica gel

出典と根拠

ORDレコード
ord-6dbe666eb49f40b78d7cfc9c7ea6ecf5
出典データセット
uspto-grants-2007_10
特許番号
US07282494B2

反応ノート

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