Adenine → 9-(Phenylmethyl)-9H-purin-6-amine

HRID 1181195ノート

反応式

HRID 1181195 の反応式
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.[H-].[Na+].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CN(C=O)C>[CH2:13]([N:5]1[CH:6]=[N:7][C:8]2[C:4]1=[N:3][CH:2]=[N:1][C:9]=2[NH2:10])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 190AdenineHCID 7498Benzyl BromideHCID 24758Sodium hydride

生成物 1

HCID 202629-(Phenylmethyl)-9H-purin-6-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Adenine (1 mmol) in DMF was treated with sodium hydride (1.2 mmol) followed by benzyl bromide (1.2 mmol) at room temperature under nitrogen. The resulting mixture was warmed at 100° C. for 2 h. The cooled reaction mixture was evaporated to dryness. Extraction and chromatography afforded N9-benzyladenine.

後処理

  1. customThe cooled reaction mixture
  2. customwas evaporated to dryness
  3. extractionExtraction and chromatography

出典と根拠

ORDレコード
ord-a631dcfe8f3941e3912af92044a6d41c
出典データセット
uspto-grants-2007_10
特許番号
US07285543B2

反応ノート

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