Hydrochloric Acid → HCID 178492758、化合物
反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([O:11][CH3:12])[NH:8][N:7]=1)=[O:5])C.[OH-].[Na+].Cl>O1CCCC1>[CH3:12][O:11][C:9]1[NH:8][N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=1参加物
5
実験手順
5-Methoxy-1H-pyrazole-3-carboxylic acid ethyl ester (120 mg, 0.71 mmol) was dissolved in tetrahydrofuran (THF) (2 mL). After addition of sodium hydroxide (2M in water; 1 mL) the mixture was stirred under reflux for 2 h. The reaction mixture was cooled to room temperature and acidified (pH 3) by addition of hydrochloric acid and extracted with ethyl acetate (3×20 ml). The extract was dried over sodium sulfate and evaporated to yield 86 mg (86%) of a white solid.
後処理
- temperatureunder reflux for 2 h
- extractionextracted with ethyl acetate (3×20 ml)
- dry with materialThe extract was dried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-d7723e383c844cd2a32938495f0b05b9
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07285569B2
反応ノート
読み込み中…