反応式
O.[C:2]1([CH3:12])[CH:7]=[CH:6]C(S(O)(=O)=O)=CC=1.[CH2:13]([CH:15]1[O:17][CH2:16]1)[F:14].C1(C[NH:22][C:23]2[C:24]([S:42][CH3:43])=[N:25][N:26]3[C:31]([C:32]4[C:37]([CH3:38])=[CH:36][C:35]([CH3:39])=[CH:34][C:33]=4[O:40][CH3:41])=[CH:30][CH:29]=[CH:28][C:27]=23)CC1>COCCOC>[CH:7]1([CH2:6][CH:16]([NH:22][C:23]2[C:24]([S:42][CH3:43])=[N:25][N:26]3[C:31]([C:32]4[C:37]([CH3:38])=[CH:36][C:35]([CH3:39])=[CH:34][C:33]=4[O:40][CH3:41])=[CH:30][CH:29]=[CH:28][C:27]=23)[CH:15]([OH:17])[CH2:13][F:14])[CH2:2][CH2:12]1参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
p-Toluenesulfonic acid hydrate (40 mg) and epifluorohydrin (0.15 mL) [CAS No. 503-09-3] were added to a solution of N-cyclopropylmethyl-N-[7-(2-methoxy-4,6-dimethylphenyl)-2-(methylsulfanyl)pyrazolo[1,5-a]pyridin-3-yl]amine (50 mg) in 1,2-dimethoxyethane (0.40 mL), and the mixture was heated to reflux for 3 hours. After cooling to room temperature, the solvent was distilled off under reduced pressure. The obtained residue was purified by basic silica gel column chromatography (ethyl acetate:n-hexane=1:5) to obtain the title compound (24 mg) as a brownish oil.
後処理
- temperaturethe mixture was heated
- temperatureto reflux for 3 hours
- distillationthe solvent was distilled off under reduced pressure
- customThe obtained residue was purified by basic silica gel column chromatography (ethyl acetate:n-hexane=1:5)
出典と根拠
- ORDレコード
- ord-d2a161cff05b40f8b2691fb58f81d1cd
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07285666B2
関連ノート
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