Thionyl Chloride → Ethyl 3-(chloromethyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride
反応式
O[CH2:2][C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]2=[N:5][C:4]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].S(Cl)([Cl:19])=O>C(Cl)(Cl)Cl>[ClH:19].[Cl:19][CH2:2][C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]2=[N:5][C:4]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]参加物
4
実験手順
To a solution of ethyl 3-(hydroxymethyl)imidazo[1,2-a]pyridine-2-carboxylate (2.85 g) in chloroform (40 ml) was added thionyl chloride (8.0 ml) at room temperature, and the mixture was heated under reflux for 12 hr. The reaction solution was cooled to room temperature, and concentrated under reduced pressure. The precipitated crystals were collected by filtration, washed with diethyl ether to give the object product (3.50 g).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 12 hr
- concentrationconcentrated under reduced pressure
- filtrationThe precipitated crystals were collected by filtration
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-acfc1e9d043a447ca87311397d602527
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664380B2
反応ノート
読み込み中…