Water → 3-Ethoxythieno[2,3-b]pyrazine-6-carboxylic acid
反応式
Cl[C:2]1[N:7]=[C:6]2[S:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:5]2=[N:4][CH:3]=1.[OH-].[Na+].O.C1C[O:21][CH2:20][CH2:19]1>CO>[CH2:20]([O:21][C:2]1[N:7]=[C:6]2[S:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:5]2=[N:4][CH:3]=1)[CH3:19]参加物
6
実験手順
To a solution of methyl 3-chlorothieno[2,3-b]pyrazine-6-carboxylate 92 (0.044 mmol, 10 mg) in methanol 250 uL and THF 250 uL was added sodium hydroxide 2N in water (0.219 mmol, 109 μA) and stirred overnight at rt. The reaction mixture was quenched in 2N HCl and extracted with CH2Cl2/methanol (9/1). The organic layer was dried and concentrated under reduced pressure to give 3-ethoxythieno[2,3-b]pyrazine-6-carboxylic acid 97 (9.3 mg, 100%).
後処理
- customThe reaction mixture was quenched in 2N HCl
- extractionextracted with CH2Cl2/methanol (9/1)
- customThe organic layer was dried
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-57acba7d6d4b4dd6a83c3f0e9bd0900d
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08669256B2
反応ノート
読み込み中…