Tetrahydrofuran → 2-Ethoxythieno[2,3-b]pyrazine-6-carboxylic acid

HRID 1184931ノート

反応式

HRID 1184931 の反応式
Cl[C:2]1[N:7]=[C:6]2[CH:8]=[C:9]([C:11]([O:13]C)=[O:12])[S:10][C:5]2=[N:4][CH:3]=1.[OH-].[Na+].C1C[O:20][CH2:19][CH2:18]1>C(O)C.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>[CH2:19]([O:20][C:2]1[N:7]=[C:6]2[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[S:10][C:5]2=[N:4][CH:3]=1)[CH3:18]

参加物

6

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 86680165Methyl 2-chlorothieno[2,3-b]pyrazine-6-carboxylate

生成物 1

HCID 671255822-Ethoxythieno[2,3-b]pyrazine-6-carboxylic acid収率 61%

試薬・触媒・溶媒 2

HCID 311Citric Acid溶媒HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of methyl 2-chlorothieno[3,2-b]pyrazine-6-carboxylate 22 (100 mg, 0.437 mmol) in THF (1.8 mL) and ethanol (1.2 mL) was added 2N sodium hydroxide (1.09 mL, 2.19 mmol). The reaction was stirred overnight at 50° C. The reaction mixture was poured in citric acid solution and the resulting precipitate was collected, washed with water and dried to give crude 2-ethoxythieno[2,3-b]pyrazine-6-carboxylic acid (60 mg, 61%). (m/z)=225 (M+H)+.

後処理

  1. customthe resulting precipitate was collected
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-9edd452b5e164985b399193c5d342150
出典データセット
uspto-grants-2014_03
特許番号
US08669256B2

反応ノート

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