Sebacoyl chloride → HCID 58526174、化合物

HRID 1184993

反応式

HRID 1184993 の反応式
[CH:1]1([NH:7][C:8](=[N:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[O:9][N:10]2[C:15]([CH3:17])([CH3:16])[CH2:14][CH:13]([OH:18])[CH2:12][C:11]2([CH3:20])[CH3:19])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:28](Cl)(=[O:40])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37](Cl)=[O:38]>CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[CH:22]1([NH:21][C:8]([O:9][N:10]2[C:11]([CH3:20])([CH3:19])[CH2:12][CH:13]([O:18][C:28](=[O:40])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37]([O:18][CH:13]3[CH2:12][C:11]([CH3:19])([CH3:20])[N:10]([O:9][C:8](=[N:7][CH:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)[NH:21][CH:22]4[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]4)[C:15]([CH3:17])([CH3:16])[CH2:14]3)=[O:38])[CH2:14][C:15]2([CH3:16])[CH3:17])=[N:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

参加物

5

反応物 2

HCID 66072Sebacoyl chlorideHCID 58526170HCID 58526170、化合物2 回

生成物 1

HCID 58526174HCID 58526174、化合物収率 100.3%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 1049Pyridine溶媒

実験手順

To a solution of 1,3-dicyclohexyl-2-(4-hydroxy-2,2,6,6-tetramethyl-piperidin-1-yl)-isourea [compound 8 prepared according to Example 8] (8.35 g, 22 mmol) and 4-dimethylaminopyridine (160 mg) in pyridine (20 ml) is added sebacoylchloride (2.5 g, 10.5 mmol). The mixture is stirred at room temperature for 22 hours and then diluted with ice-water (250 ml). The precipitate is filtered off, washed with water and dried to afford 9.75 g of the title compound as an off-white solid.

後処理

  1. filtrationThe precipitate is filtered off
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-c5bef321700e4ba792cf4b6bdd9e1a47
出典データセット
uspto-grants-2014_03
特許番号
US08669398B2

関連ノート

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