Potassium Acetate → 1-Methyl-5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-ylboronic Acid

温度

50 °C

A 50-mL round-bottomed flask equipped with a magnetic stirrer and a reflux condenser was charged with 153a (200 mg, 0.68 mmol), bis(pinacolato)diboron (Pin2B2, 863 mg, 3.40 mmol), Pd2(dba)3 (55 mg, 0.060 mmol), X-Phos (60 mg, 0.12 mmol), potassium acetate (60 mg, 1.36 mmol), and 1,4-dioxane (10 mL). The system was evacuated and then refilled with N2. It was then heated at 50° C. for 2 h. After completion of the reaction, the mixture was filtered and the solid was washed with ethyl acetate (10 mL). The combined filtrate was evaporated under reduced pressure to afford 153b as a pale yellow solid, which was used in the next step. MS-ESI: [M+H]+ 305.1.

1. customA 50-mL round-bottomed flask equipped with a magnetic stirrer and a reflux condenser
2. customThe system was evacuated
3. additionrefilled with N2
4. customAfter completion of the reaction
5. filtrationthe mixture was filtered
6. washthe solid was washed with ethyl acetate (10 mL)
7. customThe combined filtrate was evaporated under reduced pressure

ORDレコード

ord-dd1cbffdce8a4663a8fc25c4c3edb7f0

出典データセット

uspto-grants-2014_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08669251B2