Sodium Hydroxide → HCID 21973691、化合物

HRID 11855

反応式

HRID 11855 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][CH2:12][C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19]C)=[O:18])=[CH:15][CH:14]=2)[CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.C1COCC1>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]([OH:19])=[O:18])=[CH:21][CH:22]=2)[CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 21973698Methyl 4-(8-quinolylaminomethyl)benzoate

生成物 1

HCID 21973691HCID 21973691、化合物収率 58.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The compound obtained in Example 16-1 (1 g) was dissolved in methanol (10 ml), and 1 mol/l aqueous solution of sodium hydroxide (10 ml) was added. The reaction solution was dissolved in THF (10 ml). After the reaction for 7 hours, the reaction solution was concentrated. The obtained residue was dissolved in water and 1 mol/l hydrochloric acid was gradually added while stirring to obtain a precipitate. The precipitate was collected by filtration through glass filter G4 and washed with water to obtain the title compound (560.1 mg) as a pale yellow solid.

後処理

  1. customAfter the reaction for 7 hours
  2. concentrationthe reaction solution was concentrated
  3. dissolutionThe obtained residue was dissolved in water
  4. addition1 mol/l hydrochloric acid was gradually added
  5. customto obtain a precipitate
  6. filtrationThe precipitate was collected by filtration through glass
  7. filtrationfilter G4
  8. washwashed with water

出典と根拠

ORDレコード
ord-333a087240e745fe8e998f895bad03a7
出典データセット
uspto-grants-2006_08
特許番号
US07098215B2

関連ノート

読み込み中…