Sodium Hydroxide → 2-Amino-5-chloro-3-methoxybenzoic acid

HRID 1186093ノート

反応式

HRID 1186093 の反応式
[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58566618Methyl 2-amino-5-chloro-3-methoxybenzoate

生成物 1

HCID 545958742-Amino-5-chloro-3-methoxybenzoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 2-amino-5-chloro-3-methoxybenzoate (770 mg, 3.57 mmol) was suspended in tetrahydrofuran (20 mL), 2M sodium hydroxide (5 mL) was added and the mixture was stirred at ambient temperature for 20 hours. The solution was concentrated in vacuo, then partitioned between ethyl acetate and 1M hydrochloric acid. The organic layer was washed with water, then brine, dried with sodium sulfate, decanted and concentrated in vacuo to yield 2-amino-5-chloro-3-methoxybenzoic acid.

後処理

  1. concentrationThe solution was concentrated in vacuo
  2. custompartitioned between ethyl acetate and 1M hydrochloric acid
  3. washThe organic layer was washed with water
  4. dry with materialbrine, dried with sodium sulfate
  5. customdecanted
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1edf70473893420eb539e1c3e358e451
出典データセット
uspto-grants-2014_03
特許番号
US08673897B2

反応ノート

読み込み中…