Hydrochloric Acid → 4-((((Benzyloxy)carbonyl)amino)methyl)benzoic acid

HRID 11862

反応式

HRID 11862 の反応式
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:12]([O:19][C:20](Cl)=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Cl>[OH-].[Na+]>[C:20]([NH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=1)([O:19][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:21]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10387Benzyl chloroformateHCID 655264-(Aminomethyl)Benzoic Acid

生成物 1

HCID 14799974-((((Benzyloxy)carbonyl)amino)methyl)benzoic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒2 回

実験手順

Commercially available 4-aminomethylbenzoic acid (5 g) was dissolved in 1 mol/l aqueous solution of sodium hydroxide (33 ml). Benzylchloroformate (5.2 ml) and 1 mol/l aqueous solution sodium hydroxide (40 ml) were gradually and simultaneously added while stirring at room temperature. After 3 hours, 1 mol/l hydrochloric acid was added to the reaction solution to adjust the pH to 3, and the deposited precipitate was collected by filtration through glass filter G4. The precipitate was washed with water and hexane, and dried under reduced pressure to obtain the title compound (8.162 g) as a white solid.

後処理

  1. additionsimultaneously added
  2. filtrationthe deposited precipitate was collected by filtration through glass
  3. filtrationfilter G4
  4. washThe precipitate was washed with water and hexane
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-4d0b5681f2aa4659be4d853e461c318f
出典データセット
uspto-grants-2006_08
特許番号
US07098215B2

関連ノート

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