Ethyl Acetate → 2-(Pyridin-3-yl)propan-2-ol

HRID 1186354ノート

反応式

HRID 1186354 の反応式
C[Mg]Br.[C:4]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)(=[O:6])[CH3:5].[Cl-].[NH4+].[C:15](OCC)(=O)C>O1CCCC1>[OH:6][C:4]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)([CH3:15])[CH3:5]

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 95893-AcetylpyridineHCID 25517Ammonium ChlorideHCID 178418573HCID 178418573、化合物

生成物 1

HCID 107254032-(Pyridin-3-yl)propan-2-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To methylmagnesium bromide (a 0.96 mol/L solution in tetrahydrofuran, 6.26 mL, 5.97 mmol), a solution of 3-acetylpyridine (362 mg, 2.99 mmol) in tetrahydrofuran (3.6 mL) was slowly added under a nitrogen atmosphere at 0° C., and the mixture was stirred at the same temperature for 1. Then, a saturated aqueous ammonium chloride solution was added to the reaction mixture, and extraction with ethyl acetate was performed, followed by washing with brine and drying over anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and thereby 3-(1-hydroxy-1-methylethyl)pyridine (Compound DG) (415 mg, yield: quantitative) was obtained.

後処理

  1. washby washing with brine
  2. dry with materialdrying over anhydrous sodium sulfate
  3. customThe solvent was evaporated off under reduced pressure

出典と根拠

ORDレコード
ord-9d93b4c14a4a40478e6c813c0675fa68
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

反応ノート

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